Vesicle-mediated transport to the plasma membrane

Across TCGA cell cohorts, RNA activity of the Vesicle-mediated transport to the plasma membrane pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PMEL, PPP2R1A, and CDR2L, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PMEL grouped by Vesicle-mediated transport to the plasma membrane-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	PMEL →	+5.066	+0.753	.004	.007	3	3
SOFT_TISSUE	PPP2R1A →	-0.608	-0.201	.003	.001	3	3
SOFT_TISSUE	CDR2L →	-1.243	-0.156	.001	<.001	3	3
SKIN	SLC35E4 →	-0.730	-0.517	.001	.007	3	2
SKIN	HPS4 →	+0.704	+0.497	.008	.009	3	2
SKIN	ST8SIA5 →	-1.738	-0.496	.003	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PMEL by Vesicle-mediated transport to the plasma membrane activity — SKIN

Explore this box plot interactively →