Cellular oxidant detoxification

Across TCGA patient cohorts, RNA activity of the Cellular oxidant detoxification pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are APCS, SNTB2_S222, and DCN, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular oxidant detoxification activity versus APCS in BRCA (Pearson r = 0.34).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	APCS →	+0.988	+0.029	<.001	<.001	3	9
GBM	SNTB2_S222 →	+0.749	+0.047	<.001	<.001	3	9
BRCA	DCN →	+1.038	+0.038	<.001	<.001	3	9
GBM	CDC5L →	-0.297	-0.041	<.001	<.001	3	8
BRCA	PODN →	+0.661	+0.026	<.001	<.001	3	8
GBM	SMARCA5 →	-0.380	-0.041	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0098869 vs APCS — BRCA

Explore this scatter interactively →