Cellular oxidant detoxification

Across TCGA patient cohorts, RNA activity of the Cellular oxidant detoxification pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LYVE1, IGFBP7, and FHL5, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular oxidant detoxification activity versus LYVE1 in COAD (Pearson r = 0.44).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	LYVE1 →	+1.095	+0.212	<.001	<.001	3	8
GBM	IGFBP7 →	+0.897	+0.177	<.001	<.001	3	8
CCRCC	FHL5 →	+0.919	+0.232	.006	<.001	3	8
CCRCC	CLEC1A →	+0.801	+0.215	<.001	<.001	3	8
GBM	DUSP1 →	+0.854	+0.161	<.001	<.001	3	8
OV	GEM →	+1.442	+0.180	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0098869 vs LYVE1 — COAD

Explore this scatter interactively →