Cellular oxidant detoxification

Across TCGA cell cohorts, RNA activity of the Cellular oxidant detoxification pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SYBU, KLK10, and P2RY2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SYBU grouped by Cellular oxidant detoxification-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	SYBU →	-1.801	-1.199	.001	<.001	3	4
LUNG_NSCLC_LUSC	KLK10 →	-2.573	-1.321	.001	<.001	3	4
LUNG_NSCLC_LUSC	P2RY2 →	-1.771	-1.510	.006	<.001	3	4
STOMACH	C17orf50 →	-0.320	-0.965	.004	.001	3	4
KIDNEY	STK32B →	+2.132	+1.388	.002	.002	3	3
LIVER	ZBTB7B →	-0.925	-1.571	.004	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SYBU by Cellular oxidant detoxification activity — OESOPHAGUS

Explore this box plot interactively →