Cellular oxidant detoxification

Across TCGA cell cohorts, RNA activity of the Cellular oxidant detoxification pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HECA, WASHC2C, and FJX1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular oxidant detoxification activity versus HECA in SOFT_TISSUE (Pearson r = -0.48).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	HECA →	-0.808	-0.274	.007	.007	3	5
PANCREAS	WASHC2C →	+1.120	+0.233	<.001	<.001	3	5
SOFT_TISSUE	FJX1 →	-1.646	-0.297	.008	.003	3	5
STOMACH	GSR →	+1.691	+0.323	<.001	.001	3	5
LUNG_NSCLC_LUAD	CDHR3 →	+1.168	+0.170	<.001	.005	3	5
LUNG_NSCLC_LUSC	GPR87 →	-4.980	-0.371	<.001	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0098869 vs HECA — SOFT_TISSUE

Explore this scatter interactively →