Folate transmembrane transport

Across TCGA patient cohorts, RNA activity of the Folate transmembrane transport pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CORO2A, LRP2, and PYCR2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Folate transmembrane transport activity versus CORO2A in LSCC (Pearson r = 0.34).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	CORO2A →	+0.608	+0.100	<.001	<.001	3	5
UCEC	LRP2 →	+0.947	+0.065	<.001	<.001	3	5
LSCC	PYCR2 →	+0.581	+0.089	<.001	<.001	3	5
HNSC	GFM1 →	+0.441	+0.198	<.001	.002	3	5
LSCC	MRPS23 →	+0.437	+0.063	<.001	<.001	3	5
HNSC	OPA1 →	+0.395	+0.113	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0098838 vs CORO2A — LSCC

Explore this scatter interactively →