Folate transmembrane transport

Across TCGA patient cohorts, RNA activity of the Folate transmembrane transport pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LRP2, TGM6, and ABCA3, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Folate transmembrane transport activity versus LRP2 in BRCA (Pearson r = 0.57).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	LRP2 →	+1.869	+0.508	<.001	<.001	3	6
LUAD	TGM6 →	-0.022	-0.342	.006	.009	3	4
LSCC	ABCA3 →	+1.573	+0.240	<.001	<.001	3	4
BRCA	LINC01615 →	-0.599	-0.654	.001	<.001	3	4
CCRCC	ACAT1 →	+0.628	+0.502	<.001	<.001	3	4
BRCA	STRBP →	+0.543	+0.497	.002	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0098838 vs LRP2 — BRCA

Explore this scatter interactively →