Folate transmembrane transport

Across TCGA cell cohorts, RNA activity of the Folate transmembrane transport pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC25A32, ABCC5, and LRP2, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SLC25A32 grouped by Folate transmembrane transport-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	SLC25A32 →	-0.305	-1.534	.004	<.001	3	10
SOFT_TISSUE	ABCC5 →	-0.198	-1.228	.004	.004	2	8
KIDNEY	LRP2 →	-0.280	-0.956	.001	.003	2	8
LUNG_SCLC	SLC46A1 →	-0.440	-1.775	<.001	.001	3	6
LUNG_NSCLC_LUSC	KIAA1549 →	-0.248	-1.435	.001	<.001	3	5
URINARY_TRACT	CFAP52 →	-0.334	-1.902	.003	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SLC25A32 by Folate transmembrane transport activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →