Folate transmembrane transport

Across TCGA cell cohorts, RNA activity of the Folate transmembrane transport pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PIP5KL1, THTPA, and SOX4, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PIP5KL1 grouped by Folate transmembrane transport-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	PIP5KL1 →	+1.453	+1.409	.004	.007	3	5
BLOOD_Leukemia	THTPA →	-0.755	-1.261	.002	.003	3	5
LUNG_NSCLC_LUSC	SOX4 →	-1.657	-1.281	.009	.002	1	6
LUNG_NSCLC_LUSC	TTC39A →	-1.634	-1.794	.001	.001	3	4
OVARY	SEMA3F →	+1.443	+0.748	.004	.008	3	4
LIVER	TRAPPC9 →	-1.085	-1.247	.006	.005	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PIP5KL1 by Folate transmembrane transport activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →