Modulation of inhibitory postsynaptic potential

Across TCGA patient cohorts, RNA activity of the Modulation of inhibitory postsynaptic potential pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ABAT, TGFBRAP1, and PARVB, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Modulation of inhibitory postsynaptic potential activity versus ABAT in BRCA (Pearson r = 0.47).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ABAT →	+1.230	+0.127	<.001	<.001	3	6
BRCA	TGFBRAP1 →	+0.213	+0.101	<.001	.002	3	5
BRCA	PARVB →	-0.562	-0.111	<.001	<.001	3	4
OV	PPP1R21 →	+0.245	+0.080	.001	.001	3	4
BRCA	SAFB2_S195 →	+0.211	+0.068	.007	<.001	3	4
BRCA	SLC2A1 →	-0.741	-0.103	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0098828 vs ABAT — BRCA

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