Modulation of inhibitory postsynaptic potential

Across TCGA patient cohorts, RNA activity of the Modulation of inhibitory postsynaptic potential pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ABAT, CCSER1, and HTR2A-AS1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Modulation of inhibitory postsynaptic potential activity versus ABAT in GBM (Pearson r = 0.35).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	ABAT →	+1.109	+0.657	<.001	.001	3	4
GBM	CCSER1 →	+0.485	+0.695	<.001	<.001	3	4
GBM	HTR2A-AS1 →	+0.326	+0.495	.001	.003	3	4
GBM	CCNL2P1 →	+0.717	+0.756	.002	<.001	3	4
BRCA	GAB1 →	+0.534	+0.489	.001	.004	2	4
BRCA	NCOA2 →	+0.560	+0.509	.004	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0098828 vs ABAT — GBM

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