Modulation of inhibitory postsynaptic potential

Across TCGA cell cohorts, RNA activity of the Modulation of inhibitory postsynaptic potential pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are UNC13B, NLGN2, and ABAT, each associated with the pathway in up to 11 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Modulation of inhibitory postsynaptic potential activity versus UNC13B in LARGE_INTESTINE (Pearson r = 0.55).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	UNC13B →	+1.264	+1.139	<.001	<.001	3	11
KIDNEY	NLGN2 →	+1.789	+1.390	<.001	<.001	3	10
BREAST	ABAT →	+1.895	+0.874	<.001	<.001	3	9
OESOPHAGUS	ABCA3 →	+1.958	+1.168	<.001	.002	2	9
KIDNEY	BORCS6 →	+0.639	+1.267	<.001	<.001	3	8
BLOOD_Leukemia	PLD2 →	+1.102	+0.885	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0098828 vs UNC13B — LARGE_INTESTINE

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