Spontaneous synaptic transmission

Across TCGA patient cohorts, RNA activity of the Spontaneous synaptic transmission pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SLC12A2, SLC12A2_S77, and AKR7A3, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Spontaneous synaptic transmission activity versus SLC12A2 in LUAD (Pearson r = 0.10).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	SLC12A2 →	+0.538	+0.120	<.001	<.001	3	6
PDAC	SLC12A2_S77 →	+0.559	+0.074	<.001	<.001	3	6
BRCA	AKR7A3 →	+0.703	+0.054	.001	<.001	3	6
GBM	SHROOM2 →	+0.340	+0.063	.001	.002	3	6
GBM	AGAP1 →	+0.271	+0.082	.006	.001	2	7
GBM	DLG3 →	+0.562	+0.076	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0098814 vs SLC12A2 — LUAD

Explore this scatter interactively →