Spontaneous synaptic transmission

Across TCGA cell cohorts, RNA activity of the Spontaneous synaptic transmission pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC27A2, KRT80, and FAM104A, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SLC27A2 grouped by Spontaneous synaptic transmission-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	SLC27A2 →	+2.326	+1.132	.007	.003	2	5
SKIN	KRT80 →	+2.077	+1.061	<.001	.006	3	4
OESOPHAGUS	FAM104A →	-0.701	-0.382	<.001	.002	3	3
BLOOD_Leukemia	PARG →	+1.009	+1.640	.003	<.001	2	4
OVARY	HACD3 →	+1.079	+0.905	<.001	.009	3	3
KIDNEY	ICOSLG →	+1.542	+1.802	.002	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SLC27A2 by Spontaneous synaptic transmission activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →