Spontaneous synaptic transmission

Across TCGA cell cohorts, RNA activity of the Spontaneous synaptic transmission pathway is significantly associated with the shRNA dependency of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KLHL22, AGFG2, and KCNK10, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, KLHL22 grouped by Spontaneous synaptic transmission-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	KLHL22 →	-0.171	-0.224	.004	.004	3	4
PANCREAS	AGFG2 →	+0.129	+0.196	.001	<.001	3	3
SOFT_TISSUE	KCNK10 →	+0.204	+1.727	<.001	<.001	3	3
SOFT_TISSUE	CHST8 →	+0.300	+1.700	<.001	<.001	3	3
SOFT_TISSUE	MYC →	+0.241	+1.385	.002	.001	3	3
LUNG_SCLC	MED12 →	+0.420	+1.399	.007	.005	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

KLHL22 by Spontaneous synaptic transmission activity — LIVER

Explore this box plot interactively →