Neurotransmitter reuptake

Across TCGA patient cohorts, RNA activity of the Neurotransmitter reuptake pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SCNM1, AKTIP, and ZNF707, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Neurotransmitter reuptake activity versus SCNM1 in CCRCC (Pearson r = -0.17).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	SCNM1 →	-0.185	-0.654	.005	.005	3	4
CCRCC	AKTIP →	-0.277	-0.642	<.001	.007	3	3
UCEC	ZNF707 →	-0.317	-0.529	.002	.001	3	3
CCRCC	TPTE2P6 →	-0.088	-0.661	<.001	<.001	3	3
CCRCC	TMEM200C →	-0.298	-0.522	<.001	.001	3	3
CCRCC	RPS27AP9 →	-0.366	-0.565	.005	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0098810 vs SCNM1 — CCRCC

Explore this scatter interactively →