Regulation of renal system process

Across TCGA patient cohorts, RNA activity of the Regulation of renal system process pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RFLNB, RSU1, and UTP18, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of renal system process activity versus RFLNB in CCRCC (Pearson r = 0.45).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	RFLNB →	+0.583	+0.130	<.001	<.001	3	6
BRCA	RSU1 →	+0.336	+0.035	<.001	<.001	3	6
BRCA	UTP18 →	-0.288	-0.034	<.001	<.001	3	6
BRCA	C1R →	+0.661	+0.058	<.001	<.001	3	6
BRCA	C1S →	+0.444	+0.043	<.001	<.001	3	6
BRCA	C7 →	+0.592	+0.048	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0098801 vs RFLNB — CCRCC

Explore this scatter interactively →