Regulation of renal system process

Across TCGA cell cohorts, RNA activity of the Regulation of renal system process pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are WDR41, CEP85, and ALX4, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, WDR41 grouped by Regulation of renal system process-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	WDR41 →	+0.478	+0.930	.001	.001	3	5
LARGE_INTESTINE	CEP85 →	+0.609	+0.989	.002	.002	3	5
OESOPHAGUS	ALX4 →	+0.988	+0.947	.001	.002	2	5
CNS	SCMH1 →	+0.409	+0.687	.003	.006	3	4
CNS	ZNF132 →	+0.514	+0.829	.004	.004	3	4
KIDNEY	CLCC1 →	+0.874	+1.305	.004	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

WDR41 by Regulation of renal system process activity — CNS

Explore this box plot interactively →