Xenophagy

Across TCGA patient cohorts, RNA activity of the Xenophagy pathway is significantly associated with the RNA expression of multiple genes, with the THYM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CICP14, NOD1, and EP300, each associated with the pathway in up to 33 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Xenophagy activity versus CICP14 in THYM (Pearson r = 0.64).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
THYM	CICP14 →	+1.513	+0.072	<.001	<.001	3	33
THCA	NOD1 →	+1.405	+0.042	<.001	<.001	3	32
DLBC	EP300 →	+1.917	+0.080	<.001	.001	3	32
DLBC	ZNFX1 →	+1.148	+0.087	<.001	<.001	3	32
DLBC	TSSK4 →	+1.268	+0.087	<.001	.001	3	32
ACC	STAT2 →	+1.041	+0.044	<.001	<.001	3	32

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0098792 vs CICP14 — THYM

Explore this scatter interactively →