Xenophagy

Across TCGA patient cohorts, RNA activity of the Xenophagy pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are IFI35, NMI, and SH3KBP1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Xenophagy activity versus IFI35 in LSCC (Pearson r = 0.37).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	IFI35 →	+0.365	+0.048	<.001	<.001	3	5
LSCC	NMI →	+0.334	+0.049	<.001	<.001	3	5
UCEC	SH3KBP1 →	+0.286	+0.058	<.001	<.001	3	4
GBM	SQOR →	+0.686	+0.066	<.001	<.001	3	4
GBM	STAT6 →	+0.611	+0.075	<.001	<.001	3	4
COAD	SEPTIN8 →	+0.337	+0.035	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0098792 vs IFI35 — LSCC

Explore this scatter interactively →