Xenophagy

Across TCGA cell cohorts, RNA activity of the Xenophagy pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RNF213, LGALS8, and TRANK1, each associated with the pathway in up to 20 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Xenophagy activity versus RNF213 in BLOOD_Lymphoma (Pearson r = 0.74).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	RNF213 →	+2.084	+0.203	<.001	<.001	3	20
LUNG_NSCLC_LUSC	LGALS8 →	+1.871	+0.254	<.001	<.001	3	18
UPPER_AERODIGESTIVE_TRACT	TRANK1 →	+1.849	+0.202	<.001	<.001	3	16
BLOOD_Lymphoma	ETV7 →	+1.448	+0.119	<.001	.008	3	15
LARGE_INTESTINE	DHX58 →	+1.449	+0.097	<.001	<.001	3	15
URINARY_TRACT	SAMD9L →	+2.627	+0.168	<.001	.002	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0098792 vs RNF213 — BLOOD_Lymphoma

Explore this scatter interactively →