Obsolete ncRNA transcription

pathway activity — cross-omics
GO:0098781Cross-omicsPROTEIN-MS → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Obsolete ncRNA transcription pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FANCF, SAYSD1, and INTS4P2, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
OVFANCF →+0.548+0.168.005.00323
BRCASAYSD1 →+1.496+2.554.003<.00132
BRCAINTS4P2 →+0.661+2.468.008.00232
COADE2F1 →+0.397+0.313.005.00832
COADHOXD1 →-0.367-0.426.001.00232
COADCALHM2 →-0.674-0.383<.001.00132
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration