Response to mitochondrial depolarisation

Across TCGA patient cohorts, RNA activity of the Response to mitochondrial depolarisation pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RPL5, RPL11, and RPL7, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to mitochondrial depolarisation activity versus RPL5 in GBM (Pearson r = -0.06).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	RPL5 →	-0.239	-0.059	.001	.004	3	7
GBM	RPL11 →	-0.162	-0.052	<.001	<.001	3	7
HNSC	RPL7 →	-0.177	-0.059	<.001	<.001	3	7
GBM	RPL3 →	-0.352	-0.061	.005	.003	3	6
CCRCC	RPS2 →	-0.199	-0.033	<.001	<.001	3	6
BRCA	RPL4 →	-0.378	-0.032	<.001	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0098780 vs RPL5 — GBM

Explore this scatter interactively →