Response to mitochondrial depolarisation

Across TCGA patient cohorts, RNA activity of the Response to mitochondrial depolarisation pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SQSTM1, SQSTM1_T269, and SQSTM1_S355, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to mitochondrial depolarisation activity versus SQSTM1 in LUAD (Pearson r = 0.64).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	SQSTM1 →	+0.646	+0.218	<.001	.002	3	5
LSCC	SQSTM1_T269 →	+1.041	+0.221	<.001	<.001	3	5
LSCC	SQSTM1_S355 →	+1.255	+0.299	<.001	<.001	3	4
LUAD	SQSTM1_S272 →	+1.021	+0.261	<.001	<.001	2	4
OV	SQSTM1_S28 →	+1.095	+0.303	<.001	<.001	3	3
LSCC	SQSTM1_S291 →	+1.027	+0.221	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0098780 vs SQSTM1 — LUAD

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