Detoxification

Across TCGA patient cohorts, RNA activity of the Detoxification pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are U2SURP, CDC5L, and CHERP, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Detoxification activity versus U2SURP in LSCC (Pearson r = -0.45).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	U2SURP →	-0.347	-0.048	<.001	<.001	3	8
GBM	CDC5L →	-0.245	-0.053	<.001	<.001	3	8
GBM	CHERP →	-0.234	-0.044	<.001	<.001	3	8
GBM	GTF2F1 →	-0.381	-0.056	<.001	<.001	3	8
OV	LARP7 →	-0.378	-0.035	.002	.001	3	8
OV	POLR1E →	-0.822	-0.045	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0098754 vs U2SURP — LSCC

Explore this scatter interactively →