Detoxification

Across TCGA patient cohorts, RNA activity of the Detoxification pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IL1RL1, LINC02884, and MIR223HG, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Detoxification activity versus IL1RL1 in LSCC (Pearson r = 0.13).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	IL1RL1 →	+0.830	+0.136	.002	.001	3	8
LSCC	LINC02884 →	+0.351	+0.140	<.001	.001	3	6
LUAD	MIR223HG →	+0.653	+0.174	<.001	<.001	3	6
GBM	CDC25C →	-0.750	-0.190	<.001	<.001	3	6
LSCC	FOS →	+0.853	+0.131	<.001	<.001	3	6
GBM	FANCD2 →	-0.737	-0.202	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0098754 vs IL1RL1 — LSCC

Explore this scatter interactively →