Detoxification

Across TCGA cell cohorts, RNA activity of the Detoxification pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LTBP2, NDUFC1, and GSTK1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Detoxification activity versus LTBP2 in STOMACH (Pearson r = -0.61).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	LTBP2 →	-1.945	-0.302	.005	.001	3	7
SOFT_TISSUE	NDUFC1 →	+0.888	+0.316	.001	.002	2	7
STOMACH	GSTK1 →	+1.311	+0.283	.002	.002	3	6
SOFT_TISSUE	ARHGAP23 →	-3.306	-0.304	<.001	.001	3	6
LIVER	PDE4D →	+2.091	+0.336	<.001	.005	3	5
LIVER	UGCG →	-2.209	-0.304	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0098754 vs LTBP2 — STOMACH

Explore this scatter interactively →