Bone cell development

Across TCGA patient cohorts, RNA activity of the Bone cell development pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF777, SERPINA1, and CPQ, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Bone cell development activity versus ZNF777 in LUAD (Pearson r = -0.06).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	ZNF777 →	-0.210	-0.501	.006	<.001	3	4
LUAD	SERPINA1 →	+0.928	+0.599	.004	.004	3	4
OV	CPQ →	+0.534	+0.809	<.001	<.001	3	4
OV	SERPINE1 →	+1.420	+0.828	<.001	<.001	3	4
OV	POLD2 →	-0.471	-1.137	<.001	<.001	3	4
OV	NR3C1 →	+0.806	+1.060	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0098751 vs ZNF777 — LUAD

Explore this scatter interactively →