Bone cell development

Across TCGA cell cohorts, RNA activity of the Bone cell development pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ANXA2, ADGRE5, and NRG1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Bone cell development activity versus ANXA2 in BLOOD_Lymphoma (Pearson r = 0.86).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	ANXA2 →	+3.800	+2.069	<.001	<.001	3	5
SOFT_TISSUE	ADGRE5 →	+2.787	+0.113	.007	.002	3	4
PANCREAS	NRG1 →	+4.686	+0.188	.006	.005	3	4
BLOOD_Lymphoma	GCHFR →	-3.885	-1.437	.002	.002	3	4
STOMACH	MOCOS →	+2.976	+0.417	.001	.001	3	4
SOFT_TISSUE	CYP2D6 →	-1.116	-0.141	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0098751 vs ANXA2 — BLOOD_Lymphoma

Explore this scatter interactively →