Bone cell development

Across TCGA cell cohorts, RNA activity of the Bone cell development pathway is significantly associated with the protein abundance of multiple proteins, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are FOXP1, ANXA2, and EIF4B, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Bone cell development activity versus FOXP1 in STOMACH (Pearson r = -0.82).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	FOXP1 →	-2.703	-0.422	.003	.001	2	9
LUNG_SCLC	ANXA2 →	+3.480	+0.781	<.001	.003	3	6
BREAST	EIF4B →	-0.775	-0.195	.001	<.001	3	5
BREAST	ATP6AP1 →	+1.031	+0.289	<.001	<.001	3	4
SOFT_TISSUE	ESYT2 →	+1.095	+0.136	<.001	.003	3	4
BLOOD_Lymphoma	ADAM10 →	+1.045	+1.158	<.001	.003	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0098751 vs FOXP1 — STOMACH

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