Cell aggregation

Across TCGA patient cohorts, RNA activity of the Cell aggregation pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SFRP4, ARHGEF17, and SFRP2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cell aggregation activity versus SFRP4 in COAD (Pearson r = 0.46).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	SFRP4 →	+1.003	+0.052	<.001	<.001	2	7
UCEC	ARHGEF17 →	+0.296	+0.101	.008	<.001	3	6
COAD	SFRP2 →	+0.926	+0.044	<.001	<.001	3	6
BRCA	CNN3 →	+0.420	+0.061	.001	<.001	3	6
COAD	COL11A1 →	+0.950	+0.031	<.001	.007	3	6
COAD	COL1A2 →	+0.840	+0.062	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0098743 vs SFRP4 — COAD

Explore this scatter interactively →