Cell aggregation

Across TCGA cell cohorts, RNA activity of the Cell aggregation pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are JDP2, SLC22A23, and SLC25A37, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, JDP2 grouped by Cell aggregation-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	JDP2 →	-1.284	-1.117	.005	<.001	3	4
LUNG_NSCLC_LUSC	SLC22A23 →	-1.506	-1.553	.005	<.001	3	4
BREAST	SLC25A37 →	+1.261	+0.739	.002	.007	3	4
BREAST	FAM243A →	-0.307	-0.719	.003	.007	3	4
BLOOD_Leukemia	PRRG1 →	+0.988	+0.854	.009	.004	3	4
BLOOD_Lymphoma	KLHDC8B →	-0.722	-0.552	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

JDP2 by Cell aggregation activity — SKIN

Explore this box plot interactively →