Cell aggregation

Across TCGA cell cohorts, RNA activity of the Cell aggregation pathway is significantly associated with the drug response of multiple features, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated features across cancer lineages are alpha-lipoic acid, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, alpha-lipoic acid grouped by Cell aggregation-low versus -high activity in SKIN.

Pathway-associated features by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner feature	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	alpha-lipoic acid →	+0.339	+0.105	.025	.011	1	1

Each partner links to its Q-omics profile. Showing the 1 strongest associations by consensus.

alpha-lipoic acid by Cell aggregation activity — SKIN

Explore this box plot interactively →