Import across plasma membrane

Across TCGA patient cohorts, RNA activity of the Import across plasma membrane pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PSMG4, COX19, and DGKH, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Import across plasma membrane activity versus PSMG4 in COAD (Pearson r = -0.14).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	PSMG4 →	-0.273	-0.244	.003	<.001	3	4
LUAD	COX19 →	-0.407	-0.549	<.001	.003	3	4
CCRCC	DGKH →	-0.452	-0.742	.002	.002	3	4
UCEC	BOC →	-0.944	-0.777	<.001	.001	3	4
CCRCC	GSN →	-0.493	-0.710	.004	.002	3	4
BRCA	NOD1 →	-0.391	-0.529	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0098739 vs PSMG4 — COAD

Explore this scatter interactively →