Import across plasma membrane

Across TCGA cell cohorts, RNA activity of the Import across plasma membrane pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TNFAIP8L1, HPSE, and TIMM21, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Import across plasma membrane activity versus TNFAIP8L1 in KIDNEY (Pearson r = -0.53).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	TNFAIP8L1 →	-0.943	-0.293	<.001	<.001	3	5
BLOOD_Myeloma	HPSE →	+2.598	+0.350	.001	.006	3	5
LARGE_INTESTINE	TIMM21 →	-1.022	-0.296	<.001	.004	3	5
STOMACH	LIX1L →	-2.628	-0.405	.003	<.001	3	5
CNS	ATP1A1 →	+1.045	+0.293	.001	<.001	3	5
OESOPHAGUS	RHEB →	-0.958	-0.265	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0098739 vs TNFAIP8L1 — KIDNEY

Explore this scatter interactively →