Import across plasma membrane

Across TCGA cell cohorts, RNA activity of the Import across plasma membrane pathway is significantly associated with the protein abundance of multiple proteins, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ATP1A1, SLC7A5, and ATP4A, each associated with the pathway in up to 15 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Import across plasma membrane activity versus ATP1A1 in BLOOD_Myeloma (Pearson r = 0.71).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	ATP1A1 →	+1.719	+0.445	.005	<.001	3	15
OESOPHAGUS	SLC7A5 →	+2.152	+0.292	<.001	<.001	3	10
PANCREAS	ATP4A →	+1.634	+0.260	.003	.002	1	12
LARGE_INTESTINE	SLC2A1 →	+2.440	+0.269	.001	<.001	3	9
BREAST	ATP1B1 →	+1.861	+0.290	<.001	.002	3	9
OESOPHAGUS	SLC3A2 →	+1.964	+0.294	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0098739 vs ATP1A1 — BLOOD_Myeloma

Explore this scatter interactively →