Positive regulation of the force of heart contraction

Across TCGA cell cohorts, RNA activity of the Positive regulation of the force of heart contraction pathway is significantly associated with the shRNA dependency of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC8A1, NOS1, and MYL2, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SLC8A1 grouped by Positive regulation of the force of heart contraction-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SLC8A1 →	-0.294	-1.213	<.001	.001	3	8
BONE	NOS1 →	-0.232	-1.735	.002	<.001	3	8
PANCREAS	MYL2 →	-0.296	-1.363	<.001	.001	3	5
URINARY_TRACT	SLC9A1 →	-0.499	-2.190	.001	<.001	3	5
BLOOD_Myeloma	GOLGA4 →	+0.298	+1.225	.003	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	HIPK4 →	-0.084	-1.564	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SLC8A1 by Positive regulation of the force of heart contraction activity — LARGE_INTESTINE

Explore this box plot interactively →