Macromolecule deacylation

Across TCGA patient cohorts, RNA activity of the Macromolecule deacylation pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RPL5, RPL3, and RPL7, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Macromolecule deacylation activity versus RPL5 in BRCA (Pearson r = -0.20).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RPL5 →	-0.203	-0.026	<.001	<.001	3	9
BRCA	RPL3 →	-0.285	-0.024	<.001	<.001	3	8
BRCA	RPL7 →	-0.422	-0.041	<.001	<.001	3	8
GBM	SEPTIN4 →	+0.559	+0.037	<.001	<.001	3	8
CCRCC	MAPK6_S189 →	-0.596	-0.049	.005	<.001	3	8
HNSC	PGAM1_S31 →	-0.751	-0.067	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0098732 vs RPL5 — BRCA

Explore this scatter interactively →