Macromolecule deacylation

Across TCGA cell cohorts, RNA activity of the Macromolecule deacylation pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CCDC97, RNF7, and C1orf159, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CCDC97 grouped by Macromolecule deacylation-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	CCDC97 →	+0.704	+1.345	<.001	<.001	3	4
LUNG_NSCLC_LUAD	RNF7 →	+0.453	+0.809	.004	.004	2	5
BLOOD_Lymphoma	C1orf159 →	+0.529	+1.855	.003	.001	3	3
BLOOD_Lymphoma	CCAR2 →	+0.944	+2.023	<.001	<.001	3	3
PANCREAS	GFM1 →	+0.501	+1.078	.007	.004	2	4
PANCREAS	ZNF790 →	+1.239	+1.261	.007	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CCDC97 by Macromolecule deacylation activity — LIVER

Explore this box plot interactively →