Maintenance of cell number

Across TCGA patient cohorts, RNA activity of the Maintenance of cell number pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CEP170, DBN1, and HCFC1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Maintenance of cell number activity versus CEP170 in GBM (Pearson r = 0.22).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	CEP170 →	+0.247	+0.046	.001	<.001	3	8
GBM	DBN1 →	+0.312	+0.036	<.001	<.001	3	8
HNSC	HCFC1 →	+0.179	+0.053	<.001	<.001	3	7
GBM	PSMB10_S230 →	-0.739	-0.046	<.001	<.001	3	7
HNSC	XPO1 →	+0.225	+0.082	<.001	<.001	3	6
GBM	BRD3 →	+0.401	+0.039	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0098727 vs CEP170 — GBM

Explore this scatter interactively →