Maintenance of cell number

Across TCGA patient cohorts, RNA activity of the Maintenance of cell number pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FRK, GRIA2, and CNTFR, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Maintenance of cell number activity versus FRK in COAD (Pearson r = 0.24).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	FRK →	+0.466	+2.600	.007	<.001	3	1
COAD	GRIA2 →	-0.076	-2.523	.003	<.001	3	1
COAD	CNTFR →	-1.040	-2.646	.003	<.001	3	1
COAD	BMP15 →	-0.110	-2.549	.003	<.001	3	1
COAD	PTCD3 →	+0.730	+2.646	.004	<.001	3	1
COAD	MMACHC →	+0.796	+2.600	.008	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0098727 vs FRK — COAD

Explore this scatter interactively →