Maintenance of cell number

Across TCGA cell cohorts, RNA activity of the Maintenance of cell number pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TMEM170A, SLFN5, and NFKB1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TMEM170A grouped by Maintenance of cell number-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	TMEM170A →	-0.747	-0.269	.001	.009	3	5
LARGE_INTESTINE	SLFN5 →	-2.096	-0.248	.002	<.001	3	5
LUNG_SCLC	NFKB1 →	-1.326	-0.242	.004	<.001	3	5
LUNG_SCLC	PIGK →	-0.828	-0.196	.006	.002	3	5
LIVER	HSD11B2 →	+2.715	+0.325	.001	.001	3	4
LIVER	SHISA4 →	-2.895	-0.316	.002	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TMEM170A by Maintenance of cell number activity — KIDNEY

Explore this box plot interactively →