Maintenance of cell number

Across TCGA cell cohorts, RNA activity of the Maintenance of cell number pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MAFF, TRAFD1, and SEMA3E, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Maintenance of cell number activity versus MAFF in LUNG_NSCLC_LUSC (Pearson r = -0.50).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	MAFF →	-1.329	-0.249	.002	.001	3	4
BLOOD_Leukemia	TRAFD1 →	+0.569	+0.420	.007	.007	3	4
LUNG_NSCLC_LUAD	SEMA3E →	+1.728	+0.170	.001	.007	3	4
OESOPHAGUS	CHURC1 →	-0.785	-0.245	.008	.003	2	4
CNS	TMEM41A →	+0.556	+0.202	<.001	.002	2	4
BLOOD_Lymphoma	PRKAR1B →	+1.031	+0.438	.001	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0098727 vs MAFF — LUNG_NSCLC_LUSC

Explore this scatter interactively →