Sodium ion import across plasma membrane

Across TCGA patient cohorts, RNA activity of the Sodium ion import across plasma membrane pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FAM3D, BCAS1, and ST6GALNAC1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Sodium ion import across plasma membrane activity versus FAM3D in COAD (Pearson r = 0.30).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	FAM3D →	+1.637	+0.671	<.001	.002	3	5
GBM	BCAS1 →	+2.007	+0.544	<.001	.004	2	5
LSCC	ST6GALNAC1 →	+1.664	+1.040	<.001	<.001	3	4
BRCA	ELAPOR1 →	+1.426	+0.366	.001	.002	3	4
PDAC	PDE11A →	+0.562	+0.613	<.001	<.001	3	4
PDAC	KIF12 →	+0.663	+0.487	.007	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0098719 vs FAM3D — COAD

Explore this scatter interactively →