Sodium ion import across plasma membrane

Across TCGA cell cohorts, RNA activity of the Sodium ion import across plasma membrane pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC12A2, AGR2, and DSE, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Sodium ion import across plasma membrane activity versus SLC12A2 in STOMACH (Pearson r = 0.83).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	SLC12A2 →	+3.924	+2.359	<.001	<.001	3	8
STOMACH	AGR2 →	+7.093	+1.759	.001	.001	3	7
STOMACH	DSE →	-3.131	-1.781	.001	.002	3	7
OESOPHAGUS	TMEM45B →	+4.167	+1.122	<.001	.001	3	6
STOMACH	CEACAM6 →	+4.698	+2.128	.001	<.001	3	6
LARGE_INTESTINE	PTPN14 →	-1.259	-0.976	.003	.007	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0098719 vs SLC12A2 — STOMACH

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