L-glutamate import across plasma membrane

Across TCGA patient cohorts, RNA activity of the L-glutamate import across plasma membrane pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TOLLIP, PLCH1, and ITPRID2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, L-glutamate import across plasma membrane activity versus TOLLIP in LSCC (Pearson r = 0.18).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	TOLLIP →	+0.190	+0.077	<.001	<.001	3	5
HNSC	PLCH1 →	-0.433	-0.065	.005	.007	3	5
UCEC	ITPRID2 →	+0.314	+0.072	.001	<.001	3	5
OV	CCDC9_S376 →	-0.702	-0.044	.003	.004	3	4
OV	GPX4 →	+0.331	+0.054	.002	.003	3	4
COAD	XRN2_S448 →	-0.308	-0.028	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0098712 vs TOLLIP — LSCC

Explore this scatter interactively →