L-glutamate import across plasma membrane

Across TCGA cell cohorts, RNA activity of the L-glutamate import across plasma membrane pathway is significantly associated with the drug response of multiple features, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated features across cancer lineages are NSC-87877, Vinblastine, and PD173074, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NSC-87877 grouped by L-glutamate import across plasma membrane-low versus -high activity in BONE.

Pathway-associated features by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner feature	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	NSC-87877 →	+0.798	+1.523	.049	<.001	2	2
BONE	Vinblastine →	+0.170	+1.523	.029	<.001	2	1
BONE	PD173074 →	+1.046	+1.523	.005	<.001	2	1
BONE	Dactolisib →	+0.621	+1.523	.021	<.001	2	1
BONE	CRT0105446 →	+0.938	+1.523	.021	<.001	2	1
BONE	Avagacestat →	+0.160	+1.443	.018	<.001	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NSC-87877 by L-glutamate import across plasma membrane activity — BONE

Explore this box plot interactively →