Glucose import across plasma membrane

Across TCGA patient cohorts, RNA activity of the Glucose import across plasma membrane pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC2A1, ERO1A, and CD1E, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Glucose import across plasma membrane activity versus SLC2A1 in LSCC (Pearson r = 0.25).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SLC2A1 →	+0.940	+0.428	<.001	<.001	3	7
GBM	ERO1A →	+0.977	+0.506	<.001	.002	3	6
LUAD	CD1E →	-0.899	-0.659	<.001	<.001	3	5
PDAC	GALNT16 →	-0.426	-0.840	.003	<.001	3	4
LUAD	APBA1 →	-0.400	-0.471	.001	.002	3	4
PDAC	CLEC4F →	-0.546	-0.842	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0098708 vs SLC2A1 — LSCC

Explore this scatter interactively →