Glucose import across plasma membrane

Across TCGA cell cohorts, RNA activity of the Glucose import across plasma membrane pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TTI2, AKAP3, and MED12, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TTI2 grouped by Glucose import across plasma membrane-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	TTI2 →	+0.619	+1.095	.001	.001	2	5
LUNG_SCLC	AKAP3 →	-0.686	-1.049	.008	.005	3	4
LIVER	MED12 →	+0.761	+1.167	<.001	.007	3	4
URINARY_TRACT	MXD1 →	-1.355	-1.600	.005	.009	3	4
KIDNEY	OXNAD1 →	+1.007	+1.441	<.001	<.001	3	4
KIDNEY	METTL15 →	+0.506	+1.172	.001	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TTI2 by Glucose import across plasma membrane activity — STOMACH

Explore this box plot interactively →