Glucose import across plasma membrane

Across TCGA cell cohorts, RNA activity of the Glucose import across plasma membrane pathway is significantly associated with the shRNA dependency of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CYP4F22, H3P6, and GRK3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CYP4F22 grouped by Glucose import across plasma membrane-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	CYP4F22 →	-0.194	-1.574	.006	.002	3	3
LUNG_NSCLC_LUAD	H3P6 →	+0.093	+0.669	.006	.006	3	3
LARGE_INTESTINE	GRK3 →	-0.327	-0.825	<.001	.006	3	3
LARGE_INTESTINE	BAG1 →	+0.185	+1.032	.001	<.001	3	3
LARGE_INTESTINE	FOXN1 →	-0.198	-0.862	.003	.004	2	4
SKIN	NARS1 →	+0.148	+1.525	.004	.001	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CYP4F22 by Glucose import across plasma membrane activity — LIVER

Explore this box plot interactively →